Hana Yori Dango (Boys Over Flowers)

Makino Tsukushi: a girl who comes from a poor family just wants to get through her 2 last years at Eitoku Gakuen, quietly. But once she makes herself known by standing up for her friend to the F4, the 4 most popular, powerful and rich boys at the school. She gets the red card: F4's way of a "Declaration of War". But when she doesn't let herself be beaten by them and is starting to fall for one of the F4; Hanazawa Rui. She starts to see that there is more than meets the eye...

(Source: Anime News Network)